Cannabis Compliance Audit Program

Take corrective action early, improve operational controls, and reduce regulatory, quality, and business risk.

GapCross helps cannabis operators proactively strengthen compliance by addressing state regulations, aligning with cGMP requirements in 21 CFR 111, and incorporating key preventive controls from 21 CFR 117.

This audit program helps organizations quickly identify compliance gaps, operational deficiencies, and hidden risks before they lead to incidents, complaints, or costly recalls.

A woman in a lab coat and hairnet holds a tablet and inspects cannabis plants.

Standards alignment

The Cannabis Compliance audit program integrates state regulations with current Good Manufacturing Practice from 21 CFR 111 for Dietary Supplements, and all of the 21 CFR 117 key elements for Human Food from Subparts B, C, F, and G.


Who this audit program is for

This audit program is designed specifically for organizations responsible for cannabis product quality, safety, and regulatory compliance, including:

  • Cannabis cultivators, manufacturers, processors, and packagers

  • Quality, compliance, and regulatory affairs leaders

  • Medical and adult-use cannabis operators

  • GMP, GACP, and QMS consultants serving the cannabis industry

  • Teams preparing for internal audits, certification audits, or regulatory inspections

What problems it solves

Cannabis compliance requirements often exist, but not in a way that is easy to apply, verify, or sustain.

Common challenges include:

  • GMP expectations scattered across regulations, guidance documents, and SOPs

  • Inconsistent interpretation of cannabis-specific GMP requirements

  • Reactive compliance driven by incidents or inspections

  • Limited visibility into operational risk between audits

  • Corrective actions that are documented but not effectively tracked or closed

What this audit program does

The GapCross Cannabis Compliance audit program provides a structured, repeatable way to assess and improve GMP controls across operations.

With this program, you can:

  • Evaluate cannabis operations against integrated 21 CFR 111 and 117 requirements

  • Identify compliance gaps and operational deficiencies quickly

  • Capture observations, evidence, and supporting documentation in one system

  • Assign and track corrective actions to closure

  • Maintain a current, audit-ready compliance record

How it works

  1. Conduct structured assessments aligned to regulatory requirements

  2. Record findings, observations, and supporting evidence

  3. Assign corrective actions and track progress

  4. Generate consistent, defensible audit reports

All activities are securely stored, creating a permanent compliance record that supports inspections, certifications, and continuous improvement.

Why this approach works

GapCross treats cannabis compliance as a continuous process, not a one-time audit event.

By using a standardized, control-based audit framework:

  • GMP expectations are clear, consistent, and repeatable

  • Compliance gaps are identified earlier

  • Corrective actions are visible and measurable

  • Risk is reduced proactively rather than reactively

Choose GapCross

Don’t wait for an inspection, incident, or recall to reveal compliance gaps.

Use GapCross to proactively assess cannabis GMP compliance, document corrective actions, and maintain an audit-ready operation.

Request a demo to see how GapCross can help your business.